Generation of three-dimensional heart organoids

(Tokyo Medical and Dental University) Researchers from Tokyo Medical and Dental University (TMDU) engineered three-dimensional functional heart organoids resembling the developing heart. By exposing mouse embryonic stem cells to two key proteins during heart development, the researchers were able to form heart organoids with structural, functional, and molecular similarities to the embryonic heart during development. This method could be used to study heart development and to screen for novel dr...